Palbociclib

Generic Name: Palbociclib

Brand Names: Ibrance

Palbociclib is a CDK4/6 inhibitor used with hormone therapy for advanced HR+/HER2- breast cancer.

OncologyCDK4/6 Inhibitor

What It's Used For

Palbociclib is prescribed for:

HR-positive, HER2-negative advanced breast cancer
With aromatase inhibitor (initial therapy)
With fulvestrant (after progression)
Oncology targeted therapy

First CDK4/6 inhibitor approved for breast cancer.

Side Effects

Common side effects:

Neutropenia (very common)
Fatigue
Nausea
Alopecia
Diarrhea

Serious side effects:

Severe neutropenia
Pulmonary embolism
Interstitial lung disease

Additional Information

What is Palbociclib?

Palbociclib is a CDK4/6 inhibitor that blocks cell cycle progression in cancer cells.

Neutropenia Management

Neutropenia is expected - requires regular blood count monitoring and dose adjustments.

3 Weeks On, 1 Week Off

Given in 21-day cycles with 1 week off to allow blood counts to recover.

Learn more at MedlinePlus.

Related Health Conditions

This medication is commonly used to treat or manage the following conditions:

Anemia

Anemia, characterized by a low red blood cell count, leads to fatigue and weakness due to reduced oxygen delivery; causes include blood loss, decreased production, and chronic diseases.

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Neutropenia

Neutropenia, a deficiency of infection-fighting neutrophils, arises from impaired bone marrow production (congenital/acquired), increased destruction (autoimmune), infections, medications, or toxin exposure.

Learn More

Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.

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