What It's Used For

Zoledronic acid is prescribed for:

Osteoporosis treatment and prevention (Reclast - yearly)
Paget's disease of bone
Hypercalcemia of malignancy (Zometa)
Bone metastases (Zometa - monthly)
Endocrine bone conditions

Side Effects

Common side effects:

Acute phase reaction (flu-like symptoms after infusion)
Fever
Bone, joint, or muscle pain
Headache

Serious side effects:

Osteonecrosis of the jaw
Atypical femur fractures
Hypocalcemia
Renal impairment

Additional Information

What is Zoledronic Acid?

Zoledronic acid is the most potent bisphosphonate available.

Two Formulations

Reclast: 5 mg yearly for osteoporosis
Zometa: 4 mg for cancer-related conditions

Acute Phase Reaction

Flu-like symptoms are common after the first dose but typically resolve within 3 days and are less common with subsequent doses. Acetaminophen can help.

For details, see MedlinePlus.

Related Health Conditions

This medication is commonly used to treat or manage the following conditions:

Osteoporosis

Osteoporosis weakens bones due to age, hormonal changes, poor diet, medications, certain medical conditions, and lifestyle factors, increasing fracture risk even from minor incidents.

Learn More

Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.

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Zoledronic Acid