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Upadacitinib

Generic Name: Upadacitinib

Brand Names: Rinvoq

Upadacitinib is a selective JAK1 inhibitor for multiple inflammatory conditions including RA, psoriatic arthritis, and atopic dermatitis.

RheumatologicDermatologicGastrointestinalJAK Inhibitor

What It's Used For

Side Effects

Common side effects:

  • Upper respiratory infections
  • Nausea
  • Cough
  • Fever
  • Acne

Serious side effects (boxed warnings apply):

  • Serious infections
  • Malignancy
  • Thrombosis
  • Cardiovascular events

Additional Information

What is Upadacitinib?

Upadacitinib is a selective JAK1 inhibitor with high efficacy across multiple conditions.

Selectivity

More selective for JAK1 than older JAK inhibitors, though clinical significance of this selectivity is debated.

Wide Approval

Approved for more conditions than other JAK inhibitors.

For more information, see MedlinePlus.

Related Health Conditions

This medication is commonly used to treat or manage the following conditions:

Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory bowel disease causing ulcers and inflammation in the colon and rectum, driven by immune dysfunction, genetics, and environmental factors, leading to symptoms like diarrhea and abdominal pain.

Learn More

Crohn’s disease

Crohn's disease, an inflammatory bowel disease, causes chronic digestive tract inflammation due to genetic, immune, and environmental factors, leading to debilitating symptoms and complications.

Learn More

Dermatitis

Dermatitis is skin inflammation with varied causes, including irritants, allergens, genetics (eczema), yeast overgrowth, or poor circulation, resulting in itchy rashes and dryness.

Learn More

Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.

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