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Brodalumab

Generic Name: Brodalumab

Brand Names: Siliq

Brodalumab is an IL-17 receptor blocker for moderate-to-severe plaque psoriasis, with a boxed warning for suicidal ideation.

DermatologicBiologic

What It's Used For

Brodalumab is prescribed for:

  • Moderate-to-severe plaque psoriasis
  • Patients who failed other systemic therapies
  • Dermatologic autoimmune conditions

Blocks IL-17 receptor, affecting multiple IL-17 cytokines.

Side Effects

Common side effects:

  • Arthralgia
  • Headache
  • Fatigue
  • Diarrhea
  • Oropharyngeal pain

Serious side effects:

  • ⚠️ Suicidal ideation and behavior (boxed warning)
  • Serious infections
  • Crohn's disease

Additional Information

What is Brodalumab?

Brodalumab blocks the IL-17 receptor, providing broader IL-17 pathway inhibition than antibodies targeting IL-17A alone.

Boxed Warning

Contains a boxed warning for suicidal ideation and behavior. Only available through a REMS program.

High Efficacy

Despite the warning, brodalumab is highly effective, with many patients achieving complete skin clearance.

Learn more at MedlinePlus.

Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.

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