Prucalopride is prescribed for:
- Chronic idiopathic constipation
- When laxatives have not worked
- Gastrointestinal motility improvement
It targets 5-HT4 receptors to stimulate colonic movement.
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Prucalopride
Generic Name: Prucalopride
Brand Names: Motegrity
Prucalopride is a selective serotonin receptor agonist that stimulates gut motility for chronic constipation.
Gastrointestinal
What It's Used For
Side Effects
Common side effects:
- Headache
- Abdominal pain
- Nausea
- Diarrhea
- Dizziness
Generally well-tolerated with effects improving over time.
Additional Information
What is Prucalopride?
Prucalopride is a highly selective 5-HT4 receptor agonist for chronic constipation.
How It Works
Prucalopride:
- Selectively stimulates 5-HT4 receptors in the gut
- Increases high-amplitude propagating contractions
- Accelerates colonic transit
- No significant cardiac effects (unlike older 5-HT4 agonists)
Dosing
Standard dose is 2 mg once daily. Reduce to 1 mg in patients over 65 or with severe kidney disease.
Learn more at MedlinePlus.
Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.
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