Plecanatide is prescribed for:
- Chronic idiopathic constipation
- IBS with constipation
- Gastrointestinal motility disorders
Similar mechanism to linaclotide but structured like a natural human peptide.
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Plecanatide
Generic Name: Plecanatide
Brand Names: Trulance
Plecanatide treats chronic idiopathic constipation and IBS-C by mimicking a natural intestinal peptide.
Gastrointestinal
What It's Used For
Side Effects
Common side effects:
- Diarrhea
- Abdominal distension
- Flatulence
- Abdominal tenderness
Severe diarrhea may occur and requires discontinuation.
Additional Information
What is Plecanatide?
Plecanatide is a guanylate cyclase-C agonist designed to mimic uroguanylin, a natural human intestinal peptide.
Advantages
May have pH-dependent activation that results in:
- More targeted GI activity
- Potentially less diarrhea than linaclotide
Dosing
Take once daily with or without food. Tablets can be crushed for patients with swallowing difficulties.
Learn more at MedlinePlus.
Related Health Conditions
This medication is commonly used to treat or manage the following conditions:
Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.
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