Eluxadoline is prescribed for:
- Irritable bowel syndrome with diarrhea (IBS-D)
- Gastrointestinal motility disorders
Works on opioid receptors in the gut to slow motility and reduce pain.
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Eluxadoline
Generic Name: Eluxadoline
Brand Names: Viberzi
Eluxadoline is an opioid receptor modulator for IBS with diarrhea that works locally in the gut.
Gastrointestinal
What It's Used For
Side Effects
Common side effects:
- Constipation
- Nausea
- Abdominal pain
Serious side effects:
- ⚠️ Pancreatitis (boxed warning - avoid if no gallbladder)
- Sphincter of Oddi spasm
- Serious constipation
Additional Information
What is Eluxadoline?
Eluxadoline is a mixed opioid receptor modulator (mu-agonist, delta-antagonist, kappa-agonist) that acts locally in the GI tract.
Contraindications
Do NOT use in patients:
- Without a gallbladder
- With pancreatitis history
- With biliary duct obstruction
- With alcoholism
Schedule IV
Controlled substance due to mu-opioid agonist activity, though abuse potential is low.
Learn more at MedlinePlus.
Related Health Conditions
This medication is commonly used to treat or manage the following conditions:
Irritable Bowel Syndrome
Irritable Bowel Syndrome (IBS) is a chronic gut disorder characterized by abdominal pain, bloating, and altered bowel habits, potentially stemming from gut-brain interactions, infection, or food sensitivities.
Learn More
Attention Deficit Hyperactivity Disorder (ADHD)
ADHD is a neurodevelopmental disorder marked by inattention, hyperactivity, and/or impulsivity, stemming from complex interactions between genetics, brain differences, and environmental factors, not poor parenting.
Learn More
Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.
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