Menu

Internal MedicineOur MissionOur Team
CardiovascularDermatologicEndocrineENTGastrointestinalGenito-UrinaryHematologyImmunologyMusculoskeletalNeurologicOphthalmologyPsychiatricPulmonaryGLP-1 Medications
All Health ConditionsCardiovascularDermatologicEndocrineENTGastrointestinalGenito-UrinaryHematologyImmunologyMusculoskeletalNeurologicOphthalmologyPsychiatricPulmonary
Medication GuidePatient FormsYour First VisitPatient ResourcesLab VisitsPatient PortalHIPAA PrivacyLocal VitalsFAQ
Supplements
Outbreaks
Contact Us
Back to Medication Guide

Mepolizumab

Generic Name: Mepolizumab

Brand Names: Nucala

Mepolizumab is an anti-IL-5 biologic for severe eosinophilic asthma, EGPA, and hypereosinophilic syndrome.

RespiratoryBiologicMonoclonal Antibody

What It's Used For

Mepolizumab is prescribed for:

  • Severe eosinophilic asthma
  • Eosinophilic granulomatosis with polyangiitis (EGPA)
  • Hypereosinophilic syndrome
  • Chronic rhinosinusitis with nasal polyps
  • Respiratory and immunologic conditions

Side Effects

Common side effects:

  • Headache
  • Injection site reactions
  • Back pain
  • Fatigue

Serious side effects:

  • Hypersensitivity reactions
  • Herpes zoster reactivation

Additional Information

What is Mepolizumab?

Mepolizumab is a monoclonal antibody that binds to and neutralizes IL-5, reducing eosinophil production and survival.

Multiple Indications

First biologic approved for:

  • Severe eosinophilic asthma
  • EGPA
  • Hypereosinophilic syndrome
  • Chronic rhinosinusitis with nasal polyps

Monthly Injection

Administered as subcutaneous injection every 4 weeks.

Learn more at MedlinePlus.

Related Health Conditions

This medication is commonly used to treat or manage the following conditions:

Asthma

Asthma, a chronic lung disease, causes airway inflammation and narrowing, resulting in wheezing, coughing, and shortness of breath, triggered by allergens, irritants, infections, or stress.

Learn More

Sinusitis

Sinusitis involves sinus inflammation and blockage due to infections, allergies, or structural issues, causing facial pain, pressure, and congestion, often following colds or triggered by allergens.

Learn More

Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.

Loading questions...

Ask Dr. Zimmer

Have questions about Mepolizumab? Get expert answers from Dr. Zimmer.

Privacy: Your questions are posted anonymously for your health privacy. Your name and email are only used for admin purposes.

Questions are reviewed before posting. You'll see your question and Dr. Zimmer's answer below once approved.