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Guselkumab

Generic Name: Guselkumab

Brand Names: Tremfya

Guselkumab is an IL-23 inhibitor biologic for moderate-to-severe plaque psoriasis and psoriatic arthritis.

DermatologicRheumatologicBiologic

What It's Used For

Guselkumab is prescribed for:

Targets IL-23, a cytokine upstream in the inflammatory cascade.

Side Effects

Common side effects:

  • Upper respiratory infections
  • Headache
  • Injection site reactions
  • Arthralgia

Serious side effects:

  • Serious infections
  • Hypersensitivity reactions

Additional Information

What is Guselkumab?

Guselkumab is a monoclonal antibody targeting the p19 subunit of IL-23.

Upstream Target

By blocking IL-23 (which stimulates Th17 cells to produce IL-17), guselkumab may provide more sustained disease control.

Dosing Convenience

After loading doses, maintenance is every 8 weeks, offering convenience.

For details, see MedlinePlus.

Related Health Conditions

This medication is commonly used to treat or manage the following conditions:

Coronary Artery Disease (CAD)

Coronary Artery Disease (CAD) results from plaque buildup in coronary arteries (atherosclerosis), restricting blood flow and potentially causing angina, heart attack, or heart failure, influenced by factors like high blood pressure and cholesterol.

Learn More

Heart Failure Due to Coronary Artery Disease

Heart failure stemming from coronary artery disease arises from narrowed arteries restricting blood flow, weakening or stiffening the heart muscle and reducing its pumping efficiency.

Learn More

Osteoarthritis

Osteoarthritis, a common degenerative joint disease, causes pain, stiffness, and reduced motion due to cartilage breakdown from aging, genetics, obesity, injuries, or repetitive stress.

Learn More

Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.

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