- Energy imbalance: Calorie intake that consistently exceeds calories burned, though the drivers of that imbalance differ greatly from person to person.
- Genetics: Body weight and fat distribution run strongly in families.
- Medical conditions: An underactive thyroid (hypothyroidism), polycystic ovary syndrome, and other hormonal disorders can promote weight gain.
- Medications: Some antidepressants, steroids, insulin, and seizure medicines are associated with weight gain.
- Sleep and stress: Short sleep and chronic stress alter appetite hormones and increase cravings.
- Environment and habits: Calorie-dense foods, large portions, and sedentary work and leisure time all contribute.
- Type 2 diabetes: Obesity is the strongest modifiable risk factor for diabetes.
- Heart and vascular disease: High blood pressure, abnormal cholesterol, heart attack, and stroke are all more common.
- Fatty liver: Fat accumulation in the liver can progress to inflammation and scarring (fatty liver disease).
- Sleep apnea: Interrupted breathing during sleep causes daytime fatigue and strains the heart.
- Joint disease: Extra load on the knees and hips accelerates osteoarthritis.
- Certain cancers: Obesity raises the risk of several cancers, including colon and uterine cancer.
- Nutrition changes: A sustainable, reduced-calorie eating pattern matters more than any specific named diet.
- Physical activity: Roughly 150 minutes of moderate activity per week, plus strength training, helps keep weight off.
- Behavioral support: Regular follow-up, self-monitoring, and realistic goal-setting improve results.
- Medications: GLP-1 receptor agonists such as semaglutide and liraglutide reduce appetite and produce substantial weight loss; metformin is sometimes used when insulin resistance is prominent.
- Bariatric surgery: For severe obesity, surgery is the most effective durable treatment and can put type 2 diabetes into remission.