Romosozumab is prescribed for:
- Postmenopausal osteoporosis at high fracture risk
- Endocrine bone conditions
- Patients with very high fracture risk
Dual mechanism: increases bone formation AND decreases bone resorption.
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Romosozumab
Generic Name: Romosozumab-aqqg
Brand Names: Evenity
Romosozumab is a sclerostin inhibitor that both builds bone and reduces bone breakdown for severe osteoporosis.
EndocrineBone HealthBiologic
What It's Used For
Side Effects
Common side effects:
- Arthralgia
- Headache
- Injection site reactions
Serious side effects (boxed warning):
- ⚠️ Increased risk of heart attack, stroke, and cardiovascular death
- Hypocalcemia
- Osteonecrosis of the jaw
- Atypical femur fractures
Additional Information
What is Romosozumab?
Romosozumab is a monoclonal antibody that inhibits sclerostin, a protein that normally inhibits bone formation.
Dual Effect
Uniquely both:
- Increases bone formation (anabolic)
- Decreases bone resorption (antiresorptive)
Cardiovascular Warning
Boxed warning for increased cardiovascular risk. Avoid in patients with recent MI or stroke.
For more information, see MedlinePlus.
Related Health Conditions
This medication is commonly used to treat or manage the following conditions:
Osteoporosis
Osteoporosis weakens bones due to age, hormonal changes, poor diet, medications, certain medical conditions, and lifestyle factors, increasing fracture risk even from minor incidents.
Learn More
Stroke
A stroke, caused by interrupted brain blood supply from blockage (ischemic) or bleeding (hemorrhagic), is a medical emergency requiring prompt treatment to minimize brain damage.
Learn More
Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.
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