Two Diseases Every Older St. Pete Resident Should Know About
If you are over 50, and especially if you have Northern European ancestry, there are two closely linked conditions worth knowing by name: polymyalgia rheumatica (PMR) and giant cell arteritis (GCA), also called temporal arteritis. Both are far more common in Florida than national averages suggest — our older, sun-seeking, largely European-descended population is essentially the demographic these diseases target.
One of them is uncomfortable but very treatable. The other can blind you in a matter of hours. Knowing the difference is one of the most useful things I can teach an older patient in St. Petersburg.
Why These Two Belong Together
PMR and GCA are cousins. They share age demographics (peak incidence in the 70s, almost never before 50), a strong female predominance, and a Northern European genetic substrate. Roughly 15 to 20% of people with PMR develop GCA, and about 40 to 50% of people with GCA have PMR-like symptoms. They are, in many ways, two expressions of the same systemic inflammatory process.
The NIH NIAMS overview of PMR and GCA is an excellent plain-language resource if you want more background.
PMR: When You Cannot Get Out of Bed
Classic PMR looks like this:
- Bilateral shoulder and hip girdle pain and stiffness
- Worst in the morning — often more than an hour of stiffness
- Trouble lifting arms to brush hair, trouble rising from a chair
- Low-grade fevers, fatigue, weight loss
- ESR and CRP markedly elevated (ESR often above 40)
- Age over 50, nearly always
If your labs are unfamiliar territory, the primer on understanding your blood work walks through ESR, CRP, and the rest.
PMR belongs in the broader family of inflammatory arthritis, but its treatment is surprisingly simple. Low-dose prednisone (typically 15 mg daily) produces a near-miraculous response within 48 to 72 hours. That response is so characteristic it is almost diagnostic: if you are not dramatically better within three days, the diagnosis is probably wrong.
We then taper slowly over 12 to 24 months. Some patients need steroid-sparing agents like methotrexate or the IL-6 inhibitor sarilumab.
For more on the condition itself, visit the dedicated page on polymyalgia rheumatica.
GCA: The Emergency You Cannot Miss
Giant cell arteritis is a vasculitis of medium and large arteries, particularly branches of the external carotid. When it involves the ophthalmic artery, it can cause irreversible blindness within hours. This is not hyperbole — I have seen it happen.
Classic GCA red flags:
- New headache, especially temporal
- Jaw claudication — your jaw aches when you chew a bagel
- Scalp tenderness — painful to comb your hair
- Visual changes — transient blur, double vision, or amaurosis fugax (a curtain falling over one eye)
- Tender, thickened, non-pulsatile temporal artery
- Age over 50 with markedly elevated ESR/CRP
Any of these in an older patient warrants same-day evaluation. A new headache in someone over 50 is never "just a headache" — it belongs in a different category than typical chronic headaches. The NINDS GCA overview and the Vasculitis Foundation GCA page are trustworthy deep dives if you want to read more.
Start Steroids First, Biopsy Second
This is one of the few places in medicine where we treat before we confirm. If GCA is strongly suspected — especially with visual symptoms — we start high-dose prednisone (40 to 60 mg daily, sometimes IV methylprednisolone) immediately, before the temporal artery biopsy. Steroids do not change biopsy findings significantly in the first 1 to 2 weeks, and every hour of delay risks permanent vision loss.
The full evaluation of temporal arteritis / giant cell arteritis typically involves:
- Urgent temporal artery biopsy (a 1 to 2 cm segment)
- Temporal and axillary artery ultrasound (the "halo sign")
- Sometimes PET-CT or MRA for large-vessel involvement
- Ophthalmology evaluation if any visual symptoms
Monitoring and Steroid-Sparing Therapy
Both diseases require long courses of steroids, which bring their own risks — bone loss, diabetes, weight gain, cataracts. We therefore:
- Start calcium, vitamin D, and often a bisphosphonate on day one
- Monitor blood pressure, glucose, and DEXA scans
- Use tocilizumab, an IL-6 inhibitor, as a steroid-sparing biologic in GCA — it lets many patients taper off prednisone much faster
- Track ESR, CRP, and symptoms at every visit
What the Prednisone Year Actually Feels Like
Diagnosis is the dramatic part. The harder part is the year or two of tapering that follows, and patients do better when they know what to expect.
Flares during the taper are common, not a failure
Stiffness that creeps back a week after a dose reduction is the most frequent reason a taper stalls. We check symptoms and CRP before each step down, and when a flare occurs we usually return to the last dose that worked rather than restarting from the top. In polymyalgia rheumatica that needs steroids for more than a year, or in temporal arteritis with repeated relapses, adding tocilizumab or methotrexate lets many patients come off prednisone sooner.
Steroids in the Florida sun
Months of prednisone thin the skin, so the forearm bruising and tearing we see in retirees who garden and fish here is more pronounced. Long sleeves, sunscreen, and a gentle moisturizer help. Prednisone also raises blood sugar, which in our summer heat and with dehydration can climb faster than expected, so we check glucose more often, and it disturbs sleep, which is why the dose is taken in the morning. Because infections are harder to fight while on steroids, we bring the shingles and pneumococcal vaccines current early in treatment; our shingles guide explains the timing.
Bone protection from day one
A year of prednisone is enough to cause meaningful bone loss and fractures, so calcium, vitamin D, and a bisphosphonate such as alendronate are started at the outset for most patients, with a bone density scan to track osteoporosis risk. Our musculoskeletal team follows the taper with rheumatology, and MedlinePlus and the MedlinePlus giant cell arteritis page are plain-language references for family members trying to understand the plan.
When to Come In Immediately
- New headache over age 50 — especially with scalp or jaw pain
- Any transient or persistent vision change
- Shoulder or hip girdle stiffness lasting more than two weeks
- Elevated ESR or CRP on recent labs you cannot explain
If you are reading this and any of it sounds like you, please do not wait. Schedule a visit with Zimmer Medical Group today — or if vision is affected, head to the emergency department. Time is vision.
