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Linezolid

Generic Name: Linezolid

Brand Names: Zyvox

Linezolid is an oxazolidinone antibiotic effective against resistant gram-positive bacteria including MRSA and VRE.

AntibioticOxazolidinone

What It's Used For

Linezolid is prescribed for:

  • MRSA infections
  • VRE infections
  • Hospital-acquired pneumonia
  • Complicated skin infections
  • Respiratory infections from resistant organisms

One of few oral options for serious resistant infections.

Side Effects

Common side effects:

  • Diarrhea
  • Nausea
  • Headache
  • Anemia and thrombocytopenia

Serious side effects:

  • Myelosuppression (monitor blood counts)
  • Serotonin syndrome with SSRIs
  • Peripheral and optic neuropathy
  • Lactic acidosis

Additional Information

What is Linezolid?

Linezolid is an oxazolidinone antibiotic that inhibits bacterial protein synthesis.

MAO Inhibition

Linezolid is a weak MAO inhibitor. Avoid:

  • SSRIs, SNRIs (serotonin syndrome risk)
  • Tyramine-rich foods
  • Sympathomimetics

Duration Limit

Generally limited to 28 days due to myelosuppression and neuropathy risks with prolonged use.

For more information, see MedlinePlus.

Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.

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