Daptomycin is prescribed for:
- Complicated skin and soft tissue infections
- Staphylococcus aureus bacteremia
- Right-sided endocarditis
- MRSA infections
- Serious gram-positive infections
NOT effective for pneumonia (inactivated by lung surfactant).
Back to Medication Guide
Daptomycin
Generic Name: Daptomycin
Brand Names: Cubicin
Daptomycin is an IV antibiotic for serious skin infections and bloodstream infections caused by resistant gram-positive bacteria.
AntibioticLipopeptide
What It's Used For
Side Effects
Common side effects:
- Diarrhea
- Vomiting
- Injection site reactions
- Headache
Serious side effects:
- Myopathy and rhabdomyolysis (monitor CPK)
- Eosinophilic pneumonia
- Peripheral neuropathy
Additional Information
What is Daptomycin?
Daptomycin is a cyclic lipopeptide antibiotic with rapid bactericidal activity against gram-positive organisms including MRSA and VRE.
CPK Monitoring
Must monitor creatine phosphokinase (CPK) weekly due to risk of muscle toxicity. Hold statins during treatment.
NOT for Pneumonia
Daptomycin is inactivated by pulmonary surfactant and should never be used for pneumonia.
Learn more at MedlinePlus.
Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.
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