Menu

Back to Medication Guide

Saxagliptin

Generic Name: Saxagliptin

Brand Names: Onglyza

Saxagliptin is a DPP-4 inhibitor that enhances the body's natural ability to lower blood sugar in type 2 diabetes.

EndocrineDiabetesDPP-4 Inhibitor

What It's Used For

Saxagliptin is prescribed for:

It works by enhancing the incretin system, which helps regulate insulin and glucagon.

Side Effects

Common side effects:

  • Upper respiratory infection
  • Urinary tract infection
  • Headache

Serious side effects:

  • Pancreatitis
  • Heart failure (caution in at-risk patients)
  • Severe joint pain
  • Allergic reactions

Additional Information

What is Saxagliptin?

Saxagliptin is a DPP-4 inhibitor that helps control blood sugar in type 2 diabetes.

How It Works

Saxagliptin:

  • Inhibits the DPP-4 enzyme
  • Increases active GLP-1 and GIP levels
  • Enhances insulin secretion when blood sugar is high
  • Reduces glucagon secretion
  • Low risk of hypoglycemia

Heart Failure Consideration

The SAVOR-TIMI trial showed increased heart failure hospitalization risk. Use with caution in patients with existing heart failure.

For more information, see MedlinePlus.

Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.

Loading questions...

Ask Dr. Zimmer

Have questions about Saxagliptin? Get expert answers from Dr. Zimmer.

Privacy: Your questions are posted anonymously for your health privacy. Your name and email are only used for admin purposes.

Questions are reviewed before posting. You'll see your question and Dr. Zimmer's answer below once approved.