Pitolisant

Generic Name: Pitolisant

Brand Names: Wakix

Pitolisant is a histamine H3 receptor antagonist used to treat excessive daytime sleepiness in narcolepsy.

NeurologicSleep

What It's Used For

Pitolisant is prescribed for:

Excessive daytime sleepiness in narcolepsy
Cataplexy in narcolepsy
Neurologic sleep disorders

First-in-class non-stimulant option for narcolepsy.

Side Effects

Common side effects:

Insomnia
Nausea
Anxiety
Headache

Unlike traditional stimulants, has low abuse potential.

Additional Information

What is Pitolisant?

Pitolisant is a first-in-class histamine 3 receptor antagonist/inverse agonist that increases histamine and other wake-promoting neurotransmitters.

Non-Stimulant Option

Unlike amphetamines and modafinil, pitolisant:

Not a controlled substance
Low abuse potential
Works through histamine system
Also helps with cataplexy

Dosing

Start at 8.9 mg daily, may increase to maximum 35.6 mg.

For details, see MedlinePlus.

Related Health Conditions

This medication is commonly used to treat or manage the following conditions:

Lupus Anticoagulant

Lupus anticoagulant is an antibody causing paradoxical prolonged clotting tests yet increasing thrombosis risk, linked to antiphospholipid syndrome and autoimmune diseases, despite not always requiring lupus diagnosis.

Learn More

Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.

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