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Fondaparinux

Generic Name: Fondaparinux Sodium

Brand Names: Arixtra

Fondaparinux is an injectable synthetic anticoagulant that selectively inhibits factor Xa.

CardiovascularAnticoagulant

What It's Used For

Fondaparinux is prescribed for:

  • DVT prophylaxis after orthopedic surgery
  • DVT and PE treatment
  • Unstable angina and NSTEMI
  • Cardiovascular anticoagulation

Synthetic pentasaccharide - cannot cause HIT.

Side Effects

Common side effects:

  • Bleeding
  • Anemia
  • Fever
  • Nausea
  • Injection site reactions

Serious side effects:

  • Major bleeding
  • Thrombocytopenia (not HIT)
  • Spinal hematoma with neuraxial anesthesia

Additional Information

What is Fondaparinux?

Fondaparinux is a synthetic factor Xa inhibitor that anticoagulates without the heparin molecule.

HIT Safe

Cannot cause heparin-induced thrombocytopenia (HIT) - useful alternative in patients with HIT history.

No Reversal Agent

No specific antidote available - protamine does not reverse fondaparinux.

For more information, see MedlinePlus.

Related Health Conditions

This medication is commonly used to treat or manage the following conditions:

Osteoarthritis

Osteoarthritis, a common degenerative joint disease, causes pain, stiffness, and reduced motion due to cartilage breakdown from aging, genetics, obesity, injuries, or repetitive stress.

Learn More

Thrombocytopenia

Thrombocytopenia, a condition of low platelet count (below 150,000/microliter), can cause easy bruising and bleeding due to impaired clotting from decreased production, increased destruction, or splenic sequestration.

Learn More

Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.

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