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Dolutegravir

Generic Name: Dolutegravir

Brand Names: Tivicay

Dolutegravir is an integrase strand transfer inhibitor (INSTI) used as part of HIV combination therapy.

AntiviralHIV

What It's Used For

Dolutegravir is prescribed for:

  • HIV-1 infection (with other antiretrovirals)
  • Treatment-naive and treatment-experienced patients
  • Pediatric HIV infection (6 years and older)
  • Immunology infectious disease

High barrier to resistance among integrase inhibitors.

Side Effects

Common side effects:

  • Insomnia
  • Headache
  • Fatigue
  • Nausea

Serious side effects:

  • Hypersensitivity reactions
  • Hepatotoxicity
  • Immune reconstitution syndrome

Additional Information

What is Dolutegravir?

Dolutegravir is a second-generation integrase inhibitor with a high barrier to resistance.

Once Daily

Can be taken once daily in most patients, with twice daily dosing needed only with certain drug interactions.

Neural Tube Defect Concern

Initial concerns about neural tube defects in pregnancy have been largely resolved with more data.

For more information, see MedlinePlus.

Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.

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