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Brexpiprazole

Generic Name: Brexpiprazole

Brand Names: Rexulti

Brexpiprazole is an atypical antipsychotic used for schizophrenia and as adjunctive therapy for major depressive disorder.

PsychiatricAntipsychotic

What It's Used For

Side Effects

Common side effects:

  • Weight gain
  • Akathisia
  • Somnolence
  • Nasopharyngitis
  • Tremor

Serious side effects:

  • Metabolic syndrome
  • Tardive dyskinesia
  • Increased mortality in elderly with dementia (boxed warning)

Additional Information

What is Brexpiprazole?

Brexpiprazole is a next-generation atypical antipsychotic related to aripiprazole but with different receptor binding profiles.

Mechanism

Brexpiprazole acts as:

  • Partial agonist at D2 and 5-HT1A receptors
  • Antagonist at 5-HT2A receptors
  • May have better tolerability profile than aripiprazole

Uses

Approved for schizophrenia and as add-on therapy when antidepressants alone aren't sufficient for depression.

Learn more at MedlinePlus.

Related Health Conditions

This medication is commonly used to treat or manage the following conditions:

Attention Deficit Hyperactivity Disorder (ADHD)

ADHD is a neurodevelopmental disorder marked by inattention, hyperactivity, and/or impulsivity, stemming from complex interactions between genetics, brain differences, and environmental factors, not poor parenting.

Learn More

Medical Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication. Your doctor can provide personalized recommendations based on your specific health condition and medical history.

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