- Healed infections: The most common cause — old fungal or bacterial infections and tuberculosis leave small scars or calcified granulomas that persist for life.
- Benign growths: Hamartomas and other noncancerous tumors.
- Inflammatory conditions: Diseases such as sarcoidosis and rheumatoid disease — a form of inflammatory arthritis — can produce lung nodules.
- Cancer: A minority of nodules are early lung cancers or, less often, cancer that has spread from elsewhere. The likelihood rises with older age, a long smoking history, larger nodule size, irregular edges, and growth over time.
- Small, low-risk nodules: Followed with periodic CT scans — typically at intervals of 3 to 12 months — to confirm they are not growing. Many need only one or two follow-up scans before monitoring can stop.
- Intermediate nodules: May warrant a PET scan, which highlights metabolically active tissue suggestive of cancer or active inflammation.
- Larger or suspicious nodules: Evaluated with biopsy — by bronchoscopy or a needle through the chest wall — or surgical removal.